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EV-associated Nef impairs the bloodbrain barrier, induces oxidative stress, promotes Alzheimers-like pathology, and contributes to axonal degeneration, whereas EV-associated Tat directly causes neurite shortening and neuronal death [59, 139, 148,149,150,151]
Joshua D Rosenblat has received research grant support from the Canadian Institute of Health Research (CIHR), Physician Services Inc (PSI) Foundation, Labatt Brain Health Network, Brain and Cognition Discovery Foundation (BCDF), Canadian Cancer Society, Canadian Psychiatric Association, Academic Scholars Award, American Psychiatric Association, American Society of Psychopharmacology, University of Toronto, University Health Network Centre for Mental Health, Joseph M
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